Total flavan glycoside from Abacopteris penangiana rhizomes and its acid hydrolysate: Characterisation and anti-benign prostatic hyperplasia potential |
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| Authors: | Han Wei Guanghua Wu Du Shi Shanshan Song Xuenong Zhang Yongfang Lei Jinlan Ruan |
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| Affiliation: | 1. Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2. Department of pharmacy, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China |
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| Abstract: | This study was conducted to characterise the flavonoid components of total flavan glycoside from Abacopteris penangiana rhizomes (TFA) and its acid hydrolysate (AHT) through HPLC–DAD–ESI–MS/MS analysis, and to investigate the hypothesis that TFA and AHT exhibit anti-benign prostatic hyperplasia (BPH) potential in castrated rats with testosterone-induced BPH. HPLC–MS/MS analysis indicated that TFA is rich in flavan-4-ol glycosides and AHT mainly contains 3-deoxygenated anthocyanidin. After 4 weeks of administration, TFA and AHT successfully decreased the prostate index and prostate specific antigen plasma concentrations in the rats. Histoarchitectural improvement in the prostate gland was also observed. Reduced dihydrotestosterone, VEGF, bFGF, EGF, and KGF levels were observed both in TFA- and AHT-treated rats. Furthermore, the prostatic expression of Blc-2 was inhibited, whereas that of Bax and p53 was activated by TFA and AHT. In conclusion, TFA and AHT have anti-BPH properties. Hence, plants with flavan glycosides have potential use in the treatment of BPH. |
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| Keywords: | Abacopteris penangiana Benign prostatic hyperplasia Dihydrotestosterone Growth factor Apoptosis |
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