| 基于拼合原理的具有姜黄素药效团的asperphenamate衍生物的合成 |
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| 引用本文： | 邹春阳,王凤秋,夏平,田家明.基于拼合原理的具有姜黄素药效团的asperphenamate衍生物的合成[J].辽宁化工,2014(11):1407-1408,1420. |
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| 作者姓名： | 邹春阳 王凤秋 夏平 田家明 |
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| 作者单位： | 辽宁卫生职业技术学院;南沙出入境检验检疫局 |
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| 基金项目： | 辽宁卫生职业技术学院科研基金资助项目,项目编号:2012Z01 |
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| 摘 要： | 开发了具有崭新抗肿瘤作用机制的天然产物姜黄素及asperphenamate的全新骨架结构。以拼合原理为基础,将两种天然产物中的活性片段进行对接以拓宽其结构类型。以光学活性的苯丙氨酸为原料,经还原、酰化、缩合、脱保护及氢解等步骤得到目标产物。所得目标产物结构均经核磁共振氢谱及高分辨质谱表征。
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| 关 键 词： | 姜黄素 asperphenamate 拼合原理 |
Synthesis of Asperphenamate Derivatives With Curcumin Pharmacophore Based on Hybridization Principle |
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| ZOU Chun-yang;WANG Feng-qiu;XIA Ping;TIAN Jia-ming.Synthesis of Asperphenamate Derivatives With Curcumin Pharmacophore Based on Hybridization Principle[J].Liaoning Chemical Industry,2014(11):1407-1408,1420. |
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| Authors: | ZOU Chun-yang;WANG Feng-qiu;XIA Ping;TIAN Jia-ming |
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| Affiliation: | ZOU Chun-yang;WANG Feng-qiu;XIA Ping;TIAN Jia-ming;Liaoning Vocational College of Health;Nansha Entry-exit Inspection and Quarantine Bureau; |
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| Abstract: | In order to develop the new skeleton of eurcumin and asperphenamate with novel antitumor mechanism, based onhybridization principle, two natural products＇ structural types were widen by docking active moiety. Using chiral phenylalanine asraw material, the target compound was obtained via reduction, acylafion, condensation, deprotection and so on. At last, thederivatives were characterized by 1H NMR and HRMS. |
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| Keywords: | curcumin asperphenamate hybridization principle |
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