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Utilization of Myosin and Actin Bundles for the Transport of Molecular Cargo |
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| Authors: | Hideyo Takatsuki Kevin M. Rice Shinichi Asano B. Scott Day Mizuki Hino Kazuhiro Oiwa Ryoki Ishikawa Yuichi Hiratsuka Taro Q. P. Uyeda Kazuhiro Kohama Eric R. Blough |
| Affiliation: | 1. Laboratory of Molecular Physiology, Room 241N Robert C. Byrd Biotechnology Science Center Department of Biological Sciences, Marshall University 1700 3rd Ave., Huntington, WV 25755–1090 (USA);2. Cell Differentiation and Development Center, Marshall University 1700 3rd Ave., Huntington, WV 25755–1090 (USA);3. Department of Chemistry, Marshall University 1700 3rd Ave., Huntington, WV 25755–1090 (USA);4. Department of Molecular and Cellular Pharmacology Gunma University Graduate School of Medicine Maebashi, Gunma 371–8511 (Japan);5. Kobe Advanced ICT Research Center National Institute of Information and Communications Technology Nishi‐ku, Kobe 651–2492 (Japan);6. Research Institute for Cell Engineering National Institute of Advanced Industrial Science and Technology Tsukuba, Ibaraki 305–8562 (Japan) |
| Abstract: | The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F‐actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin‐propelled filaments, transport molecules across a motor‐patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications. |
| Keywords: | actin bundles cargo transport fascin microchannels myosin |