山西老陈醋醋泥冻干粉对高脂饮食小鼠的降血脂与抗氧化作用

醋泥是老陈醋在陈酿过程中产生的沉淀物。本研究测定山西老陈醋醋泥冻干粉的化学成分，评价醋泥冻干粉作为膳食补充剂对高脂血症小鼠的降血脂和抗氧化作用。用醋泥冻干粉以1%或5%的剂量饲喂高脂或正常饮食的小鼠35 d，测定小鼠的各项血液生理生化指标。结果表明：补充醋泥冻干粉的高脂饮食组小鼠血清甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平显著下降，高密度脂蛋白胆固醇水平显著升高，同时小鼠血清脂质过氧化产物丙二醛含量显著减少，红细胞超氧化物歧化酶和血清过氧化氢酶的活性显著升高。补充醋泥冻干粉的正常饮食组小鼠血清脂质水平没有显著变化，但脂质过氧化作用明显减少。山西老陈醋醋泥冻干粉对高脂饮食小鼠具有显著的降血脂和抗氧化作用，这种有益作用可能归功于老陈醋醋泥冻干粉中含有的多糖、类黑精、多肽、膳食纤维、总多酚、总黄酮和川芎嗪等活性物质。

Hypolipidemic and Antioxidant Effects of Freeze-Dried Powder of Shanxi Mature Vinegar in Hyperlipidaemic Mice

The sediment of Shanxi mature vinegar produced during aging was collected and freeze-dried. In this study,
the chemical composition of the freeze-dried powder of Shanxi mature vinegar was measured and the hypolipidemic and
antioxidant effects of the freeze-dried powder as a dietary supplement were evaluated in mice fed for 35 days either a highfat
diet or a normal diet supplemented with 1% or 5% of the freeze-dried powder. Administration of the freeze-dried powder
to high-fat diet-fed mice resulted in a significant reduction the levels of serum triglyceride, total cholesterol and serum
low-density lipoprotein cholesterol, while the serum high-density lipoprotein cholesterol was significantly increased. In
addition, the amount of malondialdehyde (MDA) generated during lipid peroxidation was significantly decreased, while
the superoxide dismutase (SOD) activity of red blood cells and serum catalase (CAT) activity were significantly increased.
No significant change in serum lipid profile was observed in mice receiving dietary supplementation of the freeze-dried
powder, but blood antioxidant status was improved, as measured by SOD activity, and lipid peroxidation was reduced. These
beneficial effects of the freeze-dried powder on hyperlipidaemic mice might be attributed to its dietary fiber, polysaccharides,
peptides, melanoidins, polyphenols, flavonoids and ligustrazines.