| Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin☆ |
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| 作者姓名： | Jinglan Wu Pengfei Jiao Wei Zhuang Jingwei Zhou Hanjie Ying |
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| 作者单位： | 1.College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;2.National Engineering Technique Research Center for Biotechnology, Nanjing 211816, China;3.Jiangsu National Synergetic Innovation Center for Advanced Material, Nanjing 210009, China;4.State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing 210009, China |
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| 基金项目： | the Program for Changjiang Scholars and Innovative Research Team in University(IRT1066)，National Natural Science Foundation of China(21306086)，Applied Basic Research Programs of Science and Technology Commission Foundation of Jiangsu Province(BK20151452) |
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| 摘 要： | L-phenylalanine, one of the nine essential amino acids for the human body, is extensively used as an ingredient in food, pharmaceutical and nutrition industries. A suitable equilibrium model is required for purification of L-phenylalanine based on ion-exchange chromatography. In this work, the equilibrium uptake of L-phenylalanine on a strong acid-cation exchanger SH11 was investigated experimental y and theoretical y. A modified Donnan ion-exchange (DIX) model, which takes the activity into account, was established to predict the uptake of L-phenyl-alanine at various solution pH values. The model parameters including selectivity and mean activity coefficient in the resin phase are presented. The modified DIX model is in good agreement with the experimental data. The optimum operating pH value of 2.0, with the highest L-phenylalanine uptake on the resin, is predicted by the model. This basic information combined with the general mass transfer model wil lay the foundation for the prediction of dynamic behavior of fixed bed separation process.
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| 关 键 词： | Ion-exchange equilibrium L-phenylalanine Mathematical modeling Chromatography Mean ionic activity coefficient |
| 收稿时间： | 2015-11-16 |
Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin |
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| Jinglan Wu,Pengfei Jiao,Wei Zhuang,Jingwei Zhou,Hanjie Ying.Modified DIX model for ion-exchange equilibrium of L-phenylalanine on a strong cation-exchange resin[J].Chinese Journal of Chemical Engineering,2016,24(10):1386-1391. |
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| Authors: | Jinglan Wu Pengfei Jiao Wei Zhuang Jingwei Zhou Hanjie Ying |
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| Affiliation: | 1.College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China;2.National Engineering Technique Research Center for Biotechnology, Nanjing 211816, China;3.Jiangsu National Synergetic Innovation Center for Advanced Material, Nanjing 210009, China;4.State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing 210009, China |
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| Abstract: | L-phenylalanine, one of the nine essential amino acids for the human body, is extensively used as an ingredient in food, pharmaceutical and nutrition industries. A suitable equilibrium model is required for purification of L-phenylalanine based on ion-exchange chromatography. In this work, the equilibrium uptake of L-phenylalanine on a strong acid-cation exchanger SH11 was investigated experimental y and theoretical y. A modified Donnan ion-exchange (DIX) model, which takes the activity into account, was established to predict the uptake of L-phenyl-alanine at various solution pH values. The model parameters including selectivity and mean activity coefficient in the resin phase are presented. The modified DIX model is in good agreement with the experimental data. The optimum operating pH value of 2.0, with the highest L-phenylalanine uptake on the resin, is predicted by the model. This basic information combined with the general mass transfer model wil lay the foundation for the prediction of dynamic behavior of fixed bed separation process. |
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| Keywords: | Ion-exchange equilibrium L-phenylalanine Mathematical modeling Chromatography Mean ionic activity coefficient |
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