Operative risks of major hepatic resections

BACKGROUND/AIMS: Despite recent advances in liver surgery, major hepatic resection still remains a major operation with significant mortality and morbidity. We report our experience with major hepatic resections with particular regard to the operative risk of this procedure in cirrhotic and non-cirrhotic patients. METHODOLOGY: One hundred and ninety-three patients with malignant (77.2%) or benign (22.8%) liver tumors underwent major hepatic resection between January 1981 and December 1995. Twenty-eight patients had cirrhosis. We performed 109 right hepatectomies (56.5%), 30 right extended hepatectomies (15.5%), 32 left hepatectomies (16.6%), 15 left extended hepatectomies (7.8%) and 7 trisegmentectomies (3.6%). In 63 patients (32.6%), single or multiple associated resections were performed. Selected intraoperative and outcome data were compared in this retrospective analysis. RESULTS: There were 9 intraoperative complications: 4 injuries of the contralateral biliary duct, 4 injuries of the vena cava and 1 partial stricture of the left hepatic vein. The mean operation time was 284 +/- 97.9 min. The mean number of transfused units of blood was 1.6 +/- 1.8. The patients with operative complications required a median of 5 units of blood (range: 1-11) (p = 0.001). The intra- and postoperative mortality was 3.1%. Seventy-six patients (39.3%) developed postoperative complications, and 20.7% of these were major complications. Blood replacement was significantly higher in the cirrhotic patients (p = 0.007). No other significant differences were found between the cirrhotic and non-cirrhotic patients. CONCLUSIONS: Major hepatic resection for malignant or benign disease can be performed safely with minimal morbidity and mortality in patients with normal livers and in selected cirrhotic patients classified as Pugh A.