| 他克莫司微生物合成的研究进展 |
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| 引用本文： | 万涛,黄笛,闻建平.他克莫司微生物合成的研究进展[J].化学工业与工程,2014,31(4):69-74. |
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| 作者姓名： | 万涛 黄笛 闻建平 |
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| 作者单位： | （天津大学化工学院，系统生物工程教育部重点实验室，天津 300072） |
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| 摘 要： | 介绍了他克莫司的理化特征和免疫抑制活性，重点阐述了他克莫司发酵法生产的研究现状，着重介绍了他克莫司的合成基因簇及代谢途径研究进展，对他克莫司代谢工程改造进行综述并对今后的研究趋势进行了展望--结合系统生物学为已有的他克莫司菌株进一步进行代谢工程改造提供指导；通过合成生物学构建他克莫司合成途径全新高效的前体关键酶。
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| 关 键 词： | 他克莫司 免疫抑制活性 代谢途径 代谢工程 系统生物学 合成生物学 |
Progress in Microbial Biosynthesis of Tacrolimus |
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| Wan Tao,Huang Di,Wen Jianping.Progress in Microbial Biosynthesis of Tacrolimus[J].Chemical Industry and Engineering,2014,31(4):69-74. |
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| Authors: | Wan Tao Huang Di Wen Jianping |
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| Affiliation: | （School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin 300072, China） |
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| Abstract: | The present paper introduces recent progress in Tacrolimus＇ s physical and chemical characteristics as well as immunosuppressant activity in detail.For this purpose,the paper mainly summarizes research on fermentation production technology,the biosynthesis gene clusters and metabolic pathways.Furthermore,some successful cases of improvement about production of Tacrolimus based on metabolic engineering technology are reviewed.In future,the combination of systems biology and synthetic biology would provide rational guidance to promote the production efficiency of Tacrolimus and construct the highyield producing strains with the improved key enzymes. |
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| Keywords: | Tacrolimus immunosuppressant activity metabolic pathway metabolic engineering systems biology synthetic biology |
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