| 水飞蓟素固体脂质纳米粒的制备 |
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| 引用本文： | 王臣臣,翟光喜,田海燕. 水飞蓟素固体脂质纳米粒的制备[J]. 食品与药品, 2005, 7(4): 39-41 |
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| 作者姓名： | 王臣臣 翟光喜 田海燕 |
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| 作者单位： | 山东大学药学院,山东,济南,250012 |
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| 摘 要： | 目的 研制水飞蓟素固体脂质纳米粒。方法 以硬脂酸为载体采用溶剂乳化法制备水飞蓟素固体脂质纳米粒,并用葡聚糖凝胶层析法测定其包封率。结果 所得含药固体脂质纳米粒水分散体为稳定的乳白色混悬液,对药物的包封率为2 8.0 2 %。结论 溶剂乳化法适用于水飞蓟素固体脂质纳米粒的制备。
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| 关 键 词： | 固体脂质纳米粒 水飞蓟素 硬脂酸 |
Preparation of silymarin solid lipid nanoparticles |
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| WANG Chen-chen,ZHAI Guang-xi,TIAN Hai-yan. Preparation of silymarin solid lipid nanoparticles[J]. Food and Drug, 2005, 7(4): 39-41 |
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| Authors: | WANG Chen-chen ZHAI Guang-xi TIAN Hai-yan |
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| Abstract: | Objective To investigate silymarin solid lipid nanoparticles(SLN). Method Silymarin SLN was prepared through the solvent-emulsifying method with stearic acid as the carrier, and the encapsulation rate was determined with the Sephdex gel chromatogram. Result The loaded SLN dispersion was a stable milk-like suspension, and its encapsulation rate of silymarin was 28.02%. ConclusionThe solvent- emulsifying method is suitable for preparation of silymarin SLN. |
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| Keywords: | solid lipid nanoparticle silymarin stearic acid |
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