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Multifunctional Magnetic Optical Sensor Particles with Tunable Sizes for Monitoring Metabolic Parameters and as a Basis for Nanotherapeutics |
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| Authors: | Günter Mistlberger Klaus Koren Elisabeth Scheucher Daniel Aigner Sergey M. Borisov Armin Zankel Peter Pölt Ingo Klimant |
| Affiliation: | 1. Institute of Analytical Chemistry and Food Chemistry Graz University of Technology Stremayrgasse 16, 8010 Graz (Austria);2. Institute for Electron Microscopy Graz University of Technology Steyrergasse 17, 8010 Graz (Austria) |
| Abstract: | Magnetic optical sensor particles with multifunctional cores and shells are synthesized via a facile nanoprecipitation method and the subsequent modification of the particle shell. The hydrophobic particle core includes optical oxygen indicators, a light harvesting system, photosensitizers, and magnetic nanoparticles. Further functionalities are introduced by modifying the shell with enzymes, antibodies, multiple layers of polyelectrolytes, stimuli‐responsive polymers, and luminescent indicator dyes. The hydrodynamic diameter is tunable by varying different precipitation parameters. |
| Keywords: | Magnetic materials Sensors Stimuli‐responsive materials Polymeric materials Nanoparticles Luminescence Biomedical application |