Synthesis and self‐assembling behaviors of biotinylated pluronic/poly(lactic acid) biocompatible block copolymers in aqueous solutions |
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| Authors: | Zi Ling Li Xiang Yuan Xiong Yu Ping Li Yan Chun Gong Xing Xing Gui Xing Ou‐Yang Hua Sheng Lin Lu Juan Zhu Ji Lei Xie |
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| Affiliation: | 1. School of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China;2. School of Chemistry and Chemical Engineering, Jiangxi Science and Technology Normal University, Nanchang 330013, China;3. Jiangxi Key Lab of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China |
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| Abstract: | Four kinds of Biotinylated Pluronic/PLA block copolymers were synthesized by two‐step reactions. Pluronic were firstly modified by biotin to obtain B‐Pluronic‐OH. Biotin‐Pluronic‐PLA block copolymers were then produced by ring‐opening polymerization of the monomer L ‐lactide using Biotin‐Pluronic‐OH as the initiator and stannous octoate (Sn(Oct)2) as the catalyst. The self‐assembling behaviors of Biotin‐Pluronic‐PLA block copolymers in aqueous solutions were examined by fluorescence measurement, dynamic light scattering (DLS), and transmission electron microscopic (TEM) techniques. The size of Biotin‐F127‐PLA‐61, Biotin‐F87‐PLA, and Biotin‐P85‐PLA nanoparticles were determined to be 198, 229, and 257 nm, respectively, and their morphologies were found to be spherical micelles. Biotin‐F127‐PLA‐87 produces both spherical micelles and large compound micelles with the size of 127 and 906 nm. The cytotoxicity studies using human ovarian cancer cells OVCAR‐3 indicate that Biotin‐Pluronic‐PLA block copolymers have good biocompatibility. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010 |
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| Keywords: | block copolymers self‐assembly micelles biocompatibility drug delivery systems |
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