| 手性相转移催化剂的合成及其不对称诱导效应Ⅰ——(1S,2R)-(一)-(1-对硝基苯基-1,3-二羟基-2-丙基)三甲基碘化铵 |
| |
| 引用本文： | 华玉夏,焦晓云,刘文陆,矫桂丽,邹志琛. 手性相转移催化剂的合成及其不对称诱导效应Ⅰ——(1S,2R)-(一)-(1-对硝基苯基-1,3-二羟基-2-丙基)三甲基碘化铵[J]. 化学试剂, 2003, 0(4) |
| |
| 作者姓名： | 华玉夏 焦晓云 刘文陆 矫桂丽 邹志琛 |
| |
| 作者单位： | 山东师范大学化学系，山东师范大学化学系，山东师范大学化学系，山东师范大学化学系，山东师范大学化学系 山东 济南 250014，山东 济南 250014，山东 济南 250014，山东 济南 250014，山东 济南 250014 |
| |
| 摘 要： | 以氯霉素为原料,经水解、叔胺化、季铵化合成了光学纯(1S,2R)-(-)-(1-对硝基苯基-1,3-二羟基-2-丙基)三甲基 碘化铵,作为相转移催化剂,它对苯乙腈的α-甲基化、苯甲醛与氯仿的亲核加成均显示良好的催化作用和一定的不对称 诱导效应。
|
| 关 键 词： | 相转移催化剂 合成 (1S 2R)-(一)-(1-对硝基苯基-1 3-二羟基-2-丙基)三甲基碘化铵 不对称诱导效应 |
Synthesis and asymmetric Induction of chiral phase transfer catalysts 1--(1S,2R)-(-)-(1-paranitrophenyl-1,3-dihydrox-yl-2-propyl) trimethylammonium iodide |
| |
| HUA Yu-xia,JIAO Xiao-yun,LIU Wen-lu,JIAO Gui-li,ZOU Zhi-chen. Synthesis and asymmetric Induction of chiral phase transfer catalysts 1--(1S,2R)-(-)-(1-paranitrophenyl-1,3-dihydrox-yl-2-propyl) trimethylammonium iodide[J]. Chemical Reagents, 2003, 0(4) |
| |
| Authors: | HUA Yu-xia JIAO Xiao-yun LIU Wen-lu JIAO Gui-li ZOU Zhi-chen |
| |
| Abstract: | (1S, 2R)-(-)-(1-Para-nitrophenyl-1,3-dihydroxyl-2-propyl) trimethylammonium iodide was synthesized through hydrolysis, tert-aminolation and quaterization by beginning with chioramphenicol, and as a phase transfer catalyst, it shows good catalytic and certain asymmetric induction effect in a-methylation of phenylacetonitrile, and in addition of benzaldehyde with chloroform. |
| |
| Keywords: | phase transfer catalyst synthesis (1S 2R)-( - )-1-para-nitrophenyl-1 3-dihydroxyl-2-propyltrimeth-ylammonium iodide asymmetric induction |
| 本文献已被 CNKI 等数据库收录！ |
|
