| L-苯丙氨酸手性固定相的制备 |
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| 引用本文： | 梁莉. L-苯丙氨酸手性固定相的制备[J]. 精细化工, 2012, 29(3): 272-275 |
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| 作者姓名： | 梁莉 |
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| 作者单位： | 河北工业大学化工学院,天津,300130 |
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| 基金项目： | 河北省科技计划项目(基础研究) (08965110D) |
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| 摘 要： | L-苯丙氨酸和硬酯酰氯经酯化、酰胺化、皂化和酰氯化反应得到新型手性固定相,用FTIR、1HNMR和元素分析对手性固定相(CSP)进行了表征。将制得的手性固定相按m(CSP)∶m(硅胶)=3∶1制备薄层色谱板,采用V(乙醇)∶V(乙酸乙酯)∶V(三乙胺)=11∶5∶1作为展开体系,对手性药物度洛西汀进行拆分,其中右旋度洛西汀Rf1=0.87,左旋度洛西汀Rf2=0.75。
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| 关 键 词： | L-苯丙氨酸 衍生物 手性固定相 薄层色谱 手性拆分 分离提纯技术 |
| 收稿时间： | 2011-11-02 |
| 修稿时间： | 2011-12-27 |
L-phenylalanine preparation of Chiral Stationary Phase |
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| LIANG Li. L-phenylalanine preparation of Chiral Stationary Phase[J]. Fine Chemicals, 2012, 29(3): 272-275 |
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| Authors: | LIANG Li |
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| Affiliation: | HeBei university of technology |
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| Abstract: | L-Phenylalanine CSP was prepared from L-phenylalanine and stearoyl chloride via esterification,amidation,saponification and acid chloride reaction.The CSP was characterized by means of FTIR,1HNMR spectra and elemental analysis.Thin layer chromatography was prepared from the CSP and silica gel based on a mass ratio of 3∶ 1.Using the development system of V(ethanol)∶ V(ethyl acetate)∶ V(triethylamine)=11∶ 5∶ 1,duloxetine was separated on the TLC,with(R)-duloxetine Rf1=0.87,(S)-duloxetine Rf2=0.75. |
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| Keywords: | L-phenylalanine derivatives chiral stationary phase thin layer chromatography chiral separation separation and purification technology |
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