链格孢霉毒素的分析方法及其毒理机制研究进展

链格孢霉毒素是由链格孢霉属(Alternaria species)产生的次级代谢产物,因其大都具有细胞毒性、基因毒性、诱变性、致畸致癌性等毒性,食用被其污染的食物后会对人体健康造成严重危害。因此,筛选快速、简便的分析方法和研究其毒性作用机制都是当今的热点。本文主要概述了链格孢霉毒素的分类及理化性质,常见的分析方法及其毒理机制,旨在为链格孢霉毒素的风险评估和中毒防治等研究提供参考,同时对于人和动物的健康安全也具有重要意义。

Research progress of analytical methods and toxicological mechanisms for Alternaria mycotoxins

Alternaria species can produce a variety of metabolites,that are Alternaria mycotoxins. Alternaria mycotoxins were found with obvious toxicity and they have acute or chronic toxic effects(mutagenicity,teratogenicity and carcinogenicity,etc)on people and animals,which raised the research interest of scientists. Therefore,it is a research hotspot to screen accurate,efficient and rapid detection methods for Alternaria mycotoxins. In this study,the classification,physicochemical properties were introduced. The main analytical methods and toxicological mechanism for Alternaria mycotoxins were summarized. The trends of the novel detection technologies and toxicological mechanism for Alternaria mycotoxis were also proposed. Its aims was to provide reference for the study of the risk assessment and poisoning prevention and treatment of Alternaria mycotoxis. At the same time,it could promote the health and safety of human beings and animals.