Cordyceps sinensis CAMT 63341液态发酵多糖对小鼠若干行为学指标及免疫器官指数的影响

为评价虫草菌（Cordyceps sinensis）CAMT 63341液态发酵多糖对小鼠生长、情绪、认知和免疫的影响， 将60 只健康雄性昆明小鼠随机分成空白对照、灵芝多糖对照和Cordyceps sinensis CAMT 63341发酵多糖高、中、低 剂量饲喂组连续喂养30 d，然后行高架十字迷宫、穿梭箱、迟发型超敏反应实验，并记录小鼠体质量和免疫器官指 数。结果表明：与空白对照组相比，Cordyceps sinensis CAMT 63341发酵多糖可剂量依赖性促进小鼠生长，增加高 架迷宫开放臂次数和延长停留时间，增强穿梭箱实验中主动回避能力和缩短被动回避潜伏期，提升胸腺和脾脏器 官指数，其中，高剂量组达到显著（P＜0.05）或极显著水平（P＜0.01），接近灵芝多糖对照组，提示Cordyceps sinensis CAMT 63341液态发酵多糖具有一定的促进生长、改善情绪、增强认知和提升免疫功能。

Effect of Polysaccharides from Liquid Culture of Cordyceps sinensis CAMT 63341 on Behavior and Immunity Organ Indexes of Mice

This investigation was undertaken to evaluate the effect of polysaccharides from the liquid culture of Cordyceps sinensis CAMT 63341 on body weight, emotion, cognition and immune function in mice. Totally 60 healthy male mice were randomly divided into blank control, positive control and experimental groups. Ganoderma lucidum polysaccharides were taken as positive control, and the animals in the experimental groups were given Cordyceps sinensis CAMT 63341 polysaccharides at high, middle, and low doses, respectively. After continuous feeding for 30 days, elevated plus maze test, shuttle box test, and delayed type hypersensitivity test were conducted and the body weight and thymus and spleen organ weight to body weight ratios were recorded. Compared with the blank control group, the mice fed with Cordyceps sinensis CAMT 63341 polysaccharides exhibited dose-dependently accelerated body weight gain, increased number of open arm entries and extended time spent on the open arm of the maze, improved active avoidance response and shortened latent period of passive avoidance in shuttle box test, and increased thymus and spleen organ weight to body weight ratios, with statistically significant differences being observed in the high-dose group (P < 0.05 or 0.01), which was similarly effective to Ganoderma lucidum polysaccharides. Therefore, polysaccharides from the liquid culture of Cordyceps sinensis CAMT 63341 can promote body weight gain, improve emotion, and enhance cognition and immune function in mice.