| 中链甘油三酯干预对大鼠和小鼠体重影响的Meta分析 |
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| 引用本文： | 郭振,王建宇,周飞,谢雨婷,李露敏,文学方,余平,曾哲灵.中链甘油三酯干预对大鼠和小鼠体重影响的Meta分析[J].食品工业科技,2018,39(13):78-83,179. |
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| 作者姓名： | 郭振 王建宇 周飞 谢雨婷 李露敏 文学方 余平 曾哲灵 |
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| 作者单位： | 1. 南昌大学食品学院, 江西南昌 330031;2. 南昌大学资源环境与化工学院, 江西南昌 330031;3. 南昌大学食品科学与技术国家重点实验室, 江西南昌 330047;4. 江西省疾病预防控制中心, 江西南昌 330029 |
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| 基金项目： | 南昌大学研究生创新专项资金项目(cx2016216)。江西省科技支持计划重大项目(20143ACG70015)江西省高等学校科技落地计划项目(KJLD12012) |
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| 摘 要： | 肥胖或超重已经成为现代社会严重的流行性健康问题,是导致糖尿病、脂代谢紊乱等多种代谢疾病的危险因素之一,动物实验是临床前实验研究的重要组成部分,是研究疾病、药理作用的重要方法。本研究目的是研究中链甘油三酯(Medium-Chain Triglycerides,MCT)对大鼠和小鼠体重影响。检索了PUBMED,EMBASE和WEB of SCIENCE三个数据库相关文献,比较分析了含中链甘油三酯或椰子油饮食干预与长链甘油三酯饮食对大鼠和小鼠体重的影响,数据以标准化平均差(SMD)或加权平均差(MD)和95%置信区间(CI)表示。结果发现,中链甘油三酯的干预可以减轻大鼠SMD,-0.76(95% CI:-1.16,-0.37)]或小鼠MD,-1.39(95% CI:-2.23,-0.54)]的体重。因此,中链甘油三酯的干预对大鼠和小鼠有一定的改善体重的作用。
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| 关 键 词： | 动物模型 中链甘油三酯 Meta分析 体重 |
| 收稿时间： | 2017-11-02 |
Effect of Medium-Chain Triglycerides on Body Weight in Rat & Mice: A Meta-Analysis |
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| GUO Zhen,WANG Jian-yu,ZHOU Fei,XIE Yu-ting,LI Lu-min,WEN Xue-fang,YU Ping,ZENG Zhe-ling.Effect of Medium-Chain Triglycerides on Body Weight in Rat & Mice: A Meta-Analysis[J].Science and Technology of Food Industry,2018,39(13):78-83,179. |
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| Authors: | GUO Zhen WANG Jian-yu ZHOU Fei XIE Yu-ting LI Lu-min WEN Xue-fang YU Ping ZENG Zhe-ling |
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| Affiliation: | 1. School of Science and Technology, Nanchang University, Nanchang 330031, China;2. School of Environmental and Chemical Engineering, Nanchang University, Nanchang 330031, China;3. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China;4. Jiangxi Province Center for Disease Control and Prevention, Nanchang 330029, China |
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| Abstract: | Obesity or overweight had become a serious epidemic problem in modern society and was one of the risk factors for many metabolic diseases such as diabetes and lipid metabolism disorders. Animal experiment was an important part of preclinical studies and are good method for researching disease,pharmacological. The aim of this study was to investigate the effects of medium chain triglyceride(MCT)on body weight in rats and mice. Three databases,PUBMED,EMBASE and WEB of SCIENCE were searched,the effect of medium chain triglycerides or coconut oil diets in rat and mice with long chain triglyceride diets were compared and analyzed. The data was expressed as normalized mean difference(SMD)or weighted mean difference(WMD)and 95% confidence interval(CI). Overall,the intervention of medium chain triglycerides could reduce the body weight of rat(SMD,-0.76(95%CI:-1.16,-0.37))or mice(WMD,-1.39(95%CI:-2.23,-0.54)). The intervention of medium chain triglycerides has a certain effect on reducing body weight. |
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