A method for preparing water soluble cyclic polymers |
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| Affiliation: | 1. Clinical Microbiology and PK/PD Division, CSIR-Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu and Kashmir, India;2. Department of Biochemistry, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India;3. Academy of Scientific & Innovative Research (AcSIR), India;4. Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu and Kashmir, India |
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| Abstract: | A novel ring-closure method was developed to specifically focus on the preparation of water soluble cyclic polymers. The well-defined linear polymers were synthesized by a standard RAFT polymerization using a functional RAFT agent 1. The cyclic polymers were then obtained by virtue of an efficient bromomaleimide-thiol substitution reaction to ring-close the linear precursors. This technique is unique in that it not only produces various well-defined water soluble cyclic polymers with high efficiency and topology purity, but also employs the environmentally benign solvent, water, as the ring-closure reaction media. |
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| Keywords: | Cyclic polymer Water soluble polymer RAFT polymerization Ring-closure technique Bromomaleimide-thiol substitution reaction |
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