Monodisperse macroporous poly(glycidyl methacrylate) microspheres coated with silica: Design,preparation and characterization |
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| Affiliation: | 1. Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic;2. Polymer Institute, Slovak Academy of Sciences, Dúbravská cesta 9, 845 41 Bratislava, Slovakia;1. Department of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, PR China;2. Laboratory of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, PR China;3. Department of Chemistry, Key Lab of Organic Optoelectronics & Molecular Engineering, Tsinghua University, Beijing 100084, PR China;1. College of Medical Technology, Chengdu University of Traditional Chinese Medicine, 1166 Liutai Avenue, Chengdu, Sichuan, 611137, China;2. Research Center of Analysis and Measurement, Fudan University, 2005 Songhu Road, Shanghai, 200438, China;3. Enriching Biotechnology (Shanghai) Co. Ltd, 1688 North Guoquan Road, Shanghai, 200438, China;4. Department of Chemistry, Institutes of Biomedical Sciences, Fudan University, 2005 Songhu Road, Shanghai, 200438, China;5. Research Center of Analytical Instrumentation, Key Laboratory of Bio-resource and Eco-environment, Ministry of Education, College of Life Sciences, Sichuan University, 29 Jiuyanqiao Wangjiang Road, Chengdu, 610065, China;1. Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China;2. Department of Pharmacy, Union Hospital of Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Monosized macroporous poly(glycidyl methacrylate) (PGMA) microspheres that were 9.3 μm in size were synthesized by multistep swelling polymerization using a modified Ugelstad technique. The PGMA microspheres and their hydrolyzed analogs derived from poly(2,3-dihydroxypropyl methacrylate) (PDHPMA) were coated by silanization with tetraethoxysilane (TEOS) and (3-aminopropyl)triethoxysilane (APTES), respectively. The particles were characterized by elemental and thermogravimetric (TGA) analysis, scanning and transmission electron microscopy (SEM and TEM) coupled with an energy dispersive X-ray analysis (EDAX) and FT-IR spectroscopy to determine the SiO2 content, morphology, particle size, polydispersity and structure. These types of particles are expected to have improved biocompatibility relative to their starting polymers. |
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| Keywords: | Multistep swelling polymerization Poly(glycidyl methacrylate) Poly(2,3-dihydroxypropyl methacrylate) Monodisperse Macroporous Microspheres Silanization |
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