| 除草剂噻磺隆的合成 |
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| 引用本文： | 陆阳,冯世龙,董超宇,陶京朝,张志荣,徐固华.除草剂噻磺隆的合成[J].化工文摘,2006(3):40-41. |
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| 作者姓名： | 陆阳 冯世龙 董超宇 陶京朝 张志荣 徐固华 |
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| 作者单位： | [1]郑州大学化学系,郑州450001 [2]信阳农专有机化学教研室,河南信阳464000 [3]开封大学化工系,河南开封475000 [4]安徽省华祥农药化工公司,合肥230041 |
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| 摘 要： | 报道了以氯甲酸甲酯和2-羧甲基-3-磺酰氨基噻吩为起始原料合成除草剂噻磺隆的方法。原料2-羧甲基-3-磺酰氨基噻吩与氯甲酸甲酯生成2-甲氧羰基-3-磺酰胺基甲酸甲酯噻吩，再与2-氨基-4-甲氧基-6-甲基均三嗪反应生成噻磺隆。避免了异氰酸酯路线的种种缺点。具有收率高，含量高、成本低的特点。以2-羧甲基-3-磺酰氨基噻吩计，总收率为77.73％，原药纯度达到93.6％。
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| 关 键 词： | 噻磺隆 氯甲酸甲酯 磺酰脲 除草剂 |
Synthesis of Herbicide Thifensulfuron |
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| Authors: | Lu Yang FENG Shilong DONG Chaoyu TAO Jingzhao ZHANG Zhirong XU Guhua |
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| Affiliation: | 1 Chemistry Department of ZhengZhou University .ZhengZhou 450001 ,China;2 Office of Organic chemistry, Xinyang Agriculture College, Xinyang 464000 Henan Province,China;3 Anhui Province Huaxiang Pesticides Chemical Engineering Company Manager,Hefei 230041 ,Chian;4 College of Chemical Engineering, Kaifeng University Kaifeng 475000, Henan Province,China |
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| Abstract: | a method for preparation of thifensulfuron from methyl chloroformate and 2-methoxycarbonyl- 3- aminosulfonylthiophe as starting material was reported 2-methoxycarbonyl-3-am inosulfonylthiophene reacts with methyl chloroformate to give 2- methoxycarbonyl-3-am inosulfonylthiophene,thifensulfuron will be obtained after reaction of the above product 2-amino-4-methoxy-6-methyl-1,3,5-triazine.this is an economical method to prepare thifensulfuron in high yield and good purity, avoiding the shortcoming of the isocyanate route .the total yield reaches77.73% based on 2-methoxycarbonyl-3-am inosulfonylthiophene and the purity is 93.6%. |
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| Keywords: | thifensulfuron methyl chloroformate sulfonylureas herbicide |
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