The cortical representation of somatosensory evoked potentials of the phrenic nerve |
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Authors: | UA Zifko PJ Slomka RH Reid GB Young H Remtulla CF Bolton |
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Affiliation: | US Department of Agriculture, Agricultural Research Service, Beltsville, Maryland 20705, USA. |
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Abstract: | Parasitic third-stage larvae of the sheep abomasal nematode Haemonchus contortus develop and molt in vitro to the fourth stage (L4) in 48-72 hr, at which time they begin feeding. Coincident with the third molt, larvae begin to secrete significant amounts of protein into culture fluids, including a zinc metalloproteinase. This culture-derived zinc metalloproteinase differs from a previously described metalloproteinase from infective third-stage larvae (L32M]), which mediates the ecdysis process. These differences include time of expression, molecular mass, and substrate specificity. The purified proteinase, from cultures of L4, has a molecular weight of approximately 46 kDa, functions as an endopeptidase, and digests several native proteins of host origin including fibrinogen and fibronectin. |
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