Relationship between redox activity and chemical speciation of size-fractionated particulate matter |
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| Authors: | Leonidas Ntziachristos John R Froines Arthur K Cho Constantinos Sioutas |
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| Affiliation: | (1) Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, CA 90089, USA;(2) Center for Occupational and Environmental Health, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA;(3) Department of Molecular and Medical Pharmacology, School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA |
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| Abstract: | Background Although the mechanisms of airborne particulate matter (PM) related health effects remain incompletely understood, one emerging
hypothesis is that these adverse effects derive from oxidative stress, initiated by the formation of reactive oxygen species
(ROS) within affected cells. Typically, ROS are formed in cells through the reduction of oxygen by biological reducing agents,
with the catalytic assistance of electron transfer enzymes and redox active chemical species such as redox active organic
chemicals and metals. The purpose of this study was to relate the electron transfer ability, or redox activity, of the PM
samples to their content in polycyclic aromatic hydrocarbons and various inorganic species. The redox activity of the samples
has been shown to correlate with the induction of the stress protein, hemeoxygenase-1. |
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