Production of 2-[18F]Fluoro-2-deoxy-D-glucose at the Laboratory of Radiochemistry, University of Helsinki |
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| Authors: | T Kyllonen E -L Küamüarüainen |
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| Affiliation: | (1) Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland |
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| Abstract: | Production 2-1
8F]fluoro-2-deoxy-D-glucose (1
8F]FDG) was started at the Laboratory of Radiochemistry in 1998 when a cyclotron, specially designed for the production of short-lived positron emitters, was bought to the laboratory. The radiosynthesis of 1
8F]FDG is based on aminopolyether-mediated nucleophilic fluorination. 1
8F]Fluoride is produced by the 1
8O(p,n)1
8F nuclear reaction. 1
8F]FDG is synthesised with an automated device. The radiochemical yield of the synthesis is 50% (by the end of bombardment). Sterile and isotonic 1
8F]FDG solution is produced within 55 min. 1
8F]FDG is delivered for patient use by the medical company MAP Medical Technologies. |
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| Keywords: | |
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