甲基丙烯酸与壳聚糖接枝共聚物的制备及应用研究

以硝酸铈铵 -乙二胺四乙酸 (CAN -EDTA)为引发剂 ,研究了壳聚糖与甲基丙烯酸 (MAA)的接枝共聚反应。当c (CAN) =6 5mol/L ,c (EDTA) =3 3mol/L ,ρ(MAA) =2 0g/L ,ρ(壳聚糖 ) =5g/L ,在 5 0℃反应 2 5h ,壳聚糖接枝率、单体转化率较高。用红外光谱 (FTIR)表征了接枝共聚物。以接枝共聚物为载体制备了药物非诺落芬钙缓释片剂 ,通过测定药物片剂的非诺落芬钙在人工肠液的释放速率 ,表明药物片剂的非诺落芬钙有缓释作用。

Study on Grafting Methacrylic Acid on Chitosan and Its Application

Methacrylic acid(MAA) was grafted by copolymerization on chitosan(Ch) using ceric ammonium nitrate (CAN) and ethylenediamine tetraacetic acid (EDTA) as redox initiator in aqueous medium.It was found that the percent of grafting and conversion depended on chitosan,MAA,and CAN-EDTA concentration.The results showed that the optimum conditions were as follows:c(CAN)=6 5 mol/L,c(DETA)=3 3 mol/L,ρ(MAA)=20 g/L,ρ(Chitosan)=5 g/L,grafting temperature 50 ℃ and reaction time 2 5 h.The grafted copolymer was identified by FT-IR.Tablets containing fenoprofen calcium(FC) were prepared by direct compression of the copolymer and drug.The release rates of drugs in intestinal fluid were examined in vitro,and it showed that fenoprofen calcium in tablets was released slowly.