| ~(13)C_3-三聚氰酸、~(15)N_3-三聚氰胺的合成工艺研究 |
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| 引用本文： | 张丽雅,杨维成,罗勇.~(13)C_3-三聚氰酸、~(15)N_3-三聚氰胺的合成工艺研究[J].同位素,2010,23(3):139-143. |
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| 作者姓名： | 张丽雅 杨维成 罗勇 |
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| 作者单位： | 上海化工研究院,上海,200062 |
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| 基金项目： | 科技部转制院所专项，上海市科委科研计划项目，国家质检总局科技专项 |
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| 摘 要： | 研究了以稳定性同位素标记物13C-尿素和15N-氯化铵为原料制备质谱检测用内标物13C3-三聚氰酸、15N3-三聚氰胺的合成工艺;考察了温度、压力、溶剂等对产品收率的影响,优化了合成工艺,以良好收率合成了同位素内标试剂13C3-三聚氰酸和15N3-三聚氰胺。产品经高效液相色谱(HPLC)、质谱(MS)检测,化学纯度99%,同位素丰度98%。以上结果提示,所合成的13C3-三聚氰酸和15N3-三聚氰胺可作为同位素内标使用。
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| 关 键 词： | 13C3-三聚氰酸 15N3-三聚氰胺 合成工艺 |
Synthetic Technology of 13C3-cyanuric Acid and 15N3-melamine |
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| ZHANG Li-ya,YANG Wei-cheng,LUO Yong.Synthetic Technology of 13C3-cyanuric Acid and 15N3-melamine[J].Isotopes,2010,23(3):139-143. |
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| Authors: | ZHANG Li-ya YANG Wei-cheng LUO Yong |
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| Affiliation: | Shanghai Research Institute of Chemical Industry, Shanghai 200062, China |
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| Abstract: | The syntheses of two labeled internal standards 15N3-melamine and 13C3-cyanuric acid were studied.The influences of parameters such as temperature,pressure and solvent on the yield of products were investigated.15N3-melamine and 13C3-cyanuric acid were prepared with the common substrates 15NH4Cl and 13C-urea.Both products were shown by mass spectrometry to be target compounds.Their chemical purity were more than 99% based on HPLC analysis.The results showed that both products could be used as standards without further purification. |
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| Keywords: | 13C3-cyanuric acid 15N3-melamine synthetic technology |
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