| 简单的蛋白质组装激活三光子活性:由烷基链“奇-偶”效应调控其“之”字形提升（英文） |
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| 作者姓名： | 王君君 朱亿彩 李劲松 王爱东 余志鹏 汪森 周虹屏 |
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| 作者单位： | 1. School of Chemistry and Chemical Engineering, Institute of Physical Science and Information Technology, Center of Free Electron Laser & High Magnetic Field, Anhui University, and Key Laboratory of Structure and Functional Regulation of Hybrid Materials(Anhui University), Ministry of Education, Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province, Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials of Anhui Province;2. Key Laboratory of Drug Design, Huangshan University |
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| 基金项目： | supported by the National Natural Science Foundation of China (51972001, 52103111, and 22005002)；;the Natural Science Fund of Education Department of Anhui Province (KJ2019A0013)；;Changjiang Scholars and Innovative Research Team in University；;Anhui Province Educational Quality Engineering Foundation Program (2020xfxm67)；;the Natural Science Foundation of Anhui Educational Committee (KJHS2021B11 and KJ2021ZD0121)； |
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| 摘 要： | 设计具有高阶多光子活性、无重原子的纳米光敏剂,用于近红外(NIR-Ⅱ,1000-1700 nm)二区光诱导的深层肿瘤的光动力学治疗是一个棘手的挑战.本文利用牛血清白蛋白(BSA)与一系列无重原子光敏剂TPA-nCs(n=2-7)进行超分子组装.通过一种简单的方式,成功激活了TPA-nCs多光子荧光,并展现了“奇-偶”效应的趋势,揭示了一个有趣的构效关系.具体来说,奇、偶数烷基取代TPA-nCs偶极矩的差异,导致制备的蛋白质纳米组装体TPA-nCs@BSA呈现了“之”字型增强的三光子荧光性能.其中,TPA-7C@BSA具有最大的三光子吸收截面(可达到4.81×10-81 cm6 s2 photon-2),其在1250 nm近红外光照射下产生的活性氧物种可实现H22肿瘤高效光动力学治疗.本文报道的烷基链“奇-偶”调控为开发和改进多光子无重原子光敏材料在生物医学中的应用提供了新的思路.
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