Synthese eines neuen Thienospirans: 6,7-Dihydro-1′-methyl-spiro[benzo[b]thiophen-4(5H),2′-piperidin] |
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Authors: | Hannes Frö hlich,Gü nter Gmeiner,Fritz Sauter |
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Abstract: | Synthesis of a New Thienospiran: 6,7-Dihylro-1′-methyl-spiro[benzo[j]thioxhen-4(5H),2′-piperidine] The title spiro compound 6 – a N-methyl derivative of a new parent system - has been synthesized from nitrile 8 via 4-phenoxybutylation, followed by modified Schmidt degradation, ensuing O-deprotection and final cyclization. The constitution of the target compound and of all intermediates is established by 1H-n.m.r. and 13C-n.m.r.-spectroscopy and by microelementary analysis. |
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