| 仿生型壳聚糖-明胶/溶胶凝胶生物玻璃复合支架的制备及其矿化性能研究 |
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| 引用本文： | 赵营刚,王迎军,卢玲,陈晓峰,吴刚.仿生型壳聚糖-明胶/溶胶凝胶生物玻璃复合支架的制备及其矿化性能研究[J].硅酸盐通报,2006,25(2):8-11,22. |
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| 作者姓名： | 赵营刚 王迎军 卢玲 陈晓峰 吴刚 |
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| 作者单位： | 华南理工大学材料学院生物材料研究所,广州,510640;华南理工大学材料学院生物材料研究所,广州,510640;华南理工大学特种功能材料及其制备新技术教育部重点实验室,广州,510640;华南理工大学材料学院生物材料研究所,广州,510640;华南理工大学特种功能材料及其制备新技术教育部重点实验室,广州,510640;南方医科大学药学院,广州,510515 |
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| 基金项目： | 中国科学院资助项目
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国家重点基础研究发展计划(973计划)
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广东省博士启动基金 |
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| 摘 要： | 利用冷冻干燥法制备出用于骨和软骨组织工程的壳聚糖-明胶/溶胶凝胶生物玻璃(CS-Gel/SGBG)仿生型复合多孔支架,并进行了孔隙率的测定和显微形貌的观察;探讨了各组分不同用量对CS-Gel/SGBG复合支架显微结构的影响以及复合支架在模拟生理体液中的仿生矿化性能。研究表明,通过调节各组分的不同用量,可以制备出三维连通的复合多孔支架,且孔隙率达到90%以上;在模拟生理体液中浸泡后发现CS-Gel/SGBG支架表面有大量结晶态类骨碳酸羟基磷灰石生成,表明复合支架有良好的生物矿化性能。
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| 关 键 词： | 明胶 壳聚糖 溶胶凝胶生物玻璃 生物矿化 碳酸羟基磷灰石 |
Preparation and Study of Biomineralization Properties of the Porous Scaffolds of Chitosan - Gelatin/Sol - Gel Bioglass |
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| Zhao Yinggang,Wang Yingjun,Lu Ling,Chen Xiaofeng,Wu Gang.Preparation and Study of Biomineralization Properties of the Porous Scaffolds of Chitosan - Gelatin/Sol - Gel Bioglass[J].Bulletin of the Chinese Ceramic Society,2006,25(2):8-11,22. |
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| Authors: | Zhao Yinggang Wang Yingjun Lu Ling Chen Xiaofeng Wu Gang |
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| Affiliation: | 1 Biomaterials Research Institute, Dept. of Materials Science and Engineering, South China University of Guangzhou 510640; 2Key Laboratory of Specially Functional Materials and Advanced Manufacturing Technology of Ministry of Education, South China University of Technology, Guangzhou 510640 ; 3Dept. of Pharmaceutical Science, Southern Medical University, Guangzhou 510515 |
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| Abstract: | A new kind of porous composites used as bone and cartilage tissue engineering scaffolds was prepared from chitosan, gelatin and sol-gel bioglass by freeze-drying technique. In this work, the effect of organic and inorganic components on porosity was studied. At the same time, the biomineralization properties of porous chitosan-gelatin/sol-gel bioglass(CS-Gel/SGBG) scaffolds were also studied. The results show that the porosity of the scaffolds can be controlled by content of components; FTIR,XRD and SEM analysesindicated that hydroxylcarbonateapatite (HCA ) had formed on the surface of CS-Gel/SGBG after soaking the porous scaffold intoSBF solution, which shows that the composite scaffold possesses good mineralization properties. |
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| Keywords: | gelatin chitosan sol-gel bioglass biomineralization hydrolcarbonateapatite |
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