Crystallization of acetaminophen micro-particle using supercritical carbon dioxide |
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| Authors: | Guanghua Li Junho Chu Eun-Seok Song Kyung Ho Row Kyong-Hwan Lee Youn-Woo Lee |
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| Affiliation: | (1) Center for Advanced Bioseparation Technology, Department of Chemical Engineering, Inha University, 253 Yonghyun-dong, Nam-gu, 402-751 Incheon, Korea;(2) School of Chemical & Biological Engineering and Institute of Chemical Process, Seoul National University, San 56-1, Sillim-dong, Gwanak-gu, 151-744 Seoul, Korea;(3) Energy Conversion Research Department, Korea Institute of Energy Research, 305-343 Daejeon, Korea |
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| Abstract: | Fine particles of acetaminophen were produced by Aerosol Solvent Extraction System (ASES). The experiments were conducted
to investigate the effects of various temperatures, pressures, solvents, solution concentrations and solution feed volume
rates on particle size and morphology. The choice of solvent appears to be very important for getting specific particle shape
and size. The result shows that when ethyl acetate is used as a solvent, the irregular and acicular morphology of raw material
is recrystallized to be regular and monoclinic. The average particle size of recrystallized acetaminophen from ethyl acetate
solution has been measured to be 3–4 Μm, which was about 1/20th of raw acetaminophen in size. The particle size distribution
range also became narrow from 82 Μm to 4.9 Μm. |
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| Keywords: | Acetaminophen Supercritical Fluid Anti-solvent Particle |
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