基于Mn掺杂ZnS室温磷光量子点检测盐酸洛美沙星方法的研究

利用水相合成法制备了三巯基丙酸包裹的Mn掺杂ZnS量子点(MPA-Mn/ZnSQDs),基于该量子点的室温磷光性质,构建了一种定量检测盐酸洛美沙星(LFLX)的新方法。在最优实验条件下(pH7.4,反应时间10min),LFLX浓度在0.002~1.4μg/mL范围内与MPA-Mn/ZnSQDs的磷光猝灭强度呈良好的线性关系(r=0.993),方法检出限为0.7×10-3μg/mL。该方法相对无共存物质的干扰,并适用于LFLX眼药水及人体尿样中LFLX的快速检测。

Detection Method of Lomefloxacin Hydrochloride Based on Room Temperature Phosphorescence of Quantum Dots

The 3-mercaptopropionate acid (MPA)-capped Mn-doped ZnS quantum dots (Mn/ZnS QDs) were prepared using water phase synthesis.Based on the room temperature phosphorescence (RTP) properties of QDs,a new method for detecting lomefloxacin hydrochloride (LFLX) was established.Under the optimal conditions (pH 7.4,reaction time 10 min),the phosphorescence quenching strength ratio of MPA-Mn/ZnS QDs had a good linear relationship (r =0.993) with concentration of LFLX in the range of 0.002 to 1.4 μg/mL.The detection limit for LFLX was 0.7× 10-3 μg/mL.The proposed method was relatively free of interference from coexisting substances,and this method could be applied in the rapid detection of LFLX eye drops and urine samples.