| N-((吡咯-2-)甲基)-3-羟基萘-2-甲酰胺催化的吲哚与硝基烯烃的Friedel-Crafts烷基化反应 |
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| 引用本文： | 王文琛,黄克俊,裴学海,杨志翔,王金娟,陈治明.N-((吡咯-2-)甲基)-3-羟基萘-2-甲酰胺催化的吲哚与硝基烯烃的Friedel-Crafts烷基化反应[J].化学试剂,2017,39(5). |
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| 作者姓名： | 王文琛 黄克俊 裴学海 杨志翔 王金娟 陈治明 |
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| 作者单位： | 贵州师范大学化学与材料科学学院贵州省功能材料重点实验室,贵州贵阳,550001 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 探讨了廉价易得、环境友好的N-((吡咯-2-)甲基)-3-羟基萘-2-甲酰胺催化的吲哚与硝基烯烃不对称Friedel-Crafts烷基化反应.研究表明,在35℃条件下,CH2Cl2为溶剂、催化剂用量为10 mmol％、反应11h,吲哚及1-位或2-位被取代的吲哚与硝基烯烃能有效地进行Friedel-Crafts烷基化反应,可获得较好的产率.该反应具有催化剂经济易得且用量少、反应条件温和、环境友好、操作简单等优点.
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| 关 键 词： | 吲哚 硝基烯烃 Friedel-Crafts烷基化反应 |
3-Hydroxy-N-((pyrrolidin-2-yl) methyl)naphthalene-2-carboxamide Catalyzed Fiedel-Crafts Alkylation of Indole with Nitrostyrene |
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| WANG Wen-chen,HUANG Ke-jun,PEI Xue-hai,YANG Zhi-xiang,WANG Jin-juan,CHEN Zhi-ming.3-Hydroxy-N-((pyrrolidin-2-yl) methyl)naphthalene-2-carboxamide Catalyzed Fiedel-Crafts Alkylation of Indole with Nitrostyrene[J].Chemical Reagents,2017,39(5). |
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| Authors: | WANG Wen-chen HUANG Ke-jun PEI Xue-hai YANG Zhi-xiang WANG Jin-juan CHEN Zhi-ming |
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| Abstract: | An inexpensive and enironmentally friendly 3-hydroxy-N-((pyrrolidin-2-1y) methy)naphthalene-2-carboxamide asymmetric Friedel-Crafts alkylation of indole with3-nitrostyrenes including free-NH indoles and N or C2-substituted indoles has been developed.The reaction was 11 hours efficiently performed in the presence of (10 mmol％) at 35 ℃ in CH2C12,obtained in excellent yield.The procedure was characterized by lower amount of inexpensive catalyst,mild reaction condition,envronmentally benign and similicity. |
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| Keywords: | ndoles nitrocellulose Friedel-Crafts alkylation |
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