| 3-氨基-1,2-苯并-α-吡喃酮类衍生物的合成及抗氧化研究 |
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| 引用本文： | 闵曼,丰翠,杜俊,任建辉,陈琳. 3-氨基-1,2-苯并-α-吡喃酮类衍生物的合成及抗氧化研究[J]. 化学试剂, 2017, 39(9). DOI: 10.13822/j.cnki.hxsj.2017.09.004 |
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| 作者姓名： | 闵曼 丰翠 杜俊 任建辉 陈琳 |
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| 作者单位： | 1. 广东药科大学中药学院,广东广州,510006;2. 广东药科大学药学院,广东广州,510006 |
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| 基金项目： | 广东省科技计划项目,广东省医学科学技术研究基金项目 |
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| 摘 要： | 以2,3,4-三甲氧基苯甲醛为原料,经4步反应合成了两个未见文献报道的1,2-苯并-α-吡喃酮类衍生物,其结构经NMR和MS确证。体外抗氧化性能测试结果显示,3-苯乙酰氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮在高浓度时显示出比对照品和3-氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮更好的DPPH自由基清除活性,在低浓度时则对羟自由基表现出比对照品及3-氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮更好的抑制活性,在ABTS自由基清除实验中,低浓度的3-氨基-7,8-二甲氧基-1,2-苯并-α-吡喃酮展现出较对照品更佳的清除活性,两者具有进一步研究的价值。
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| 关 键 词： | 1,2-苯并-α-吡喃酮类化合物 合成 抗氧化 |
Synthesis and Antioxidant Activity of 3-Amino-2H-chromen-2-one Derivatives |
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| MIN Man,FENG Cui,DU Jun,REN Jian-hui,CHEN Lin. Synthesis and Antioxidant Activity of 3-Amino-2H-chromen-2-one Derivatives[J]. Chemical Reagents, 2017, 39(9). DOI: 10.13822/j.cnki.hxsj.2017.09.004 |
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| Authors: | MIN Man FENG Cui DU Jun REN Jian-hui CHEN Lin |
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| Abstract: | Two 2H-chromen-2-one derivatives were synthesized from 2,3,4-trimethoxybenzaldehyde by four steps reaction.The two compounds were synthesized and confirmed by NMR and MS.In vitro antioxidant activity test results showed that N-(7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl)-benzeneacetamide with high concentration showed higher DPPH radical scavenging activity than control and 3-amino-7,8-dimethoxy-2H-chromen-2-one.In a hydroxyl radical-scavenging test,N-(7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl)-benzeneacetamide showed better inhibitory activity than control and 3-amino-7,8-dimethoxy-2H-chromen-2-one at low concentrations.In addition,in the ABTS free radical scavenging experiment,the low concentration of 3-amino-7,8-dimethoxy-2H-chromen-2-one showed better scavenging activity than the control.Therefore,both of them have the value of further research. |
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| Keywords: | 2H-chromen-2-one derivatives synthesis antioxidant |
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