| 3,4-二甲基苯胺的合成研究 |
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| 引用本文： | 崔凯,沈宏. 3,4-二甲基苯胺的合成研究[J]. 化学试剂, 2017, 39(8). DOI: 10.13822/j.cnki.hxsj.2017.08.025 |
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| 作者姓名： | 崔凯 沈宏 |
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| 作者单位： | 1. 南京大学金陵学院化学与生命科学学院,江苏南京,210089;2. 江苏开放大学环境与生态学院,江苏南京,210036 |
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| 基金项目： | 2016年度江苏省高校“青蓝工程”项目，南京大学金陵学院2014年教学改革项目 |
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| 摘 要： | 分别以邻二甲苯和对硝基甲苯为起始原料,通过两种不同方法制备标题化合物。邻二甲苯经酰化、成肟、贝克曼重排、水解得到目标产物,纯度达98%,总收率53%。以对硝基甲苯为原料,经N-(2-甲基-5-硝基苄基)乙酰胺中间体合成标题化合物,纯度达99%,总收率50%。产物均经红外、核磁、质谱确认结构。
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| 关 键 词： | 3,4-二甲基苯胺 邻二甲苯 对硝基甲苯 |
Synthesis of 3,4-Dimethyl Aniline |
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| CUI Kai,SHEN Hong. Synthesis of 3,4-Dimethyl Aniline[J]. Chemical Reagents, 2017, 39(8). DOI: 10.13822/j.cnki.hxsj.2017.08.025 |
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| Authors: | CUI Kai SHEN Hong |
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| Abstract: | 3,4-Dimethyl aniline was prepared by two different methods with.the starting materials of o-xylene or p-nitrotoluene.The target product was obtained by the reaction of acylation,oximation,Beckmann rearrangement and hydrolysis from o-xylene.The purity was 98％,and the total yield was 53％.3,4-Dimethyl aniline was synthesized by N-(2-methyl-5-nitrobenzyl) acetamide intermediate,and the purity was 99％,the total yield was 50％.The target compounds were confirmed by IR,1 HNMR,MS. |
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| Keywords: | 3,4-dimethyl aniline o-xylene p-nitrotoluene |
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