胆汁酸溶解度的测定与数据关联

在胆汁酸结晶过程中,温度对胆汁酸在不同有机溶剂中溶解度的影响至关重要。采用平衡法结合HPLC法测定303.15~353.15 K胆酸、鹅去氧胆酸、熊去氧胆酸在5种有机溶剂中的溶解度,分别采用多项式经验方程和理想溶液方程对实验数据进行关联。结果表明,胆酸、鹅去氧胆酸、熊去氧胆酸在不同有机溶剂中的溶解度均随温度升高而增加,这两种方程均能较好地关联溶解度实验数据,其中多项式经验方程关联的相关系数均在0.98以上。

Determination and Correlation of the Solubility of Bile Acids

In the crystallization process of bile acids,temperature was vital importance for the solubility of bile acid in different organic solvents.Equilibrium method and HPLC method were combined to determine the solubility of cholic acid,chenodeoxycholic acid,and ursodeoxycholic acid in five kinds of organic solvents in the temperature of 303.15～353.15 K.The experimental data was correlated using polynomial empirical equation and ideal solution equations.The results showed that the solubility of cholic acid,chenodeoxycholic acid and ursodeoxycholic acid in different organic solvents all increased with temperature increasing.Furthermore,the two equations could both show a better correlation of solubility test data,with the correlation coefficient of polynomial empirical equation correlation above 0.98.