五氟磺草胺中间体2-丙硫基-3-三氟甲基苯酚的合成工艺改进

提出了一种制备标题化合物的改进工艺。以间三氟甲基苯酚为原料,安全无毒的3,4-2H-二氢吡喃替代剧毒品氯甲基甲醚作为酚羟基保护剂,保护后的产物经硫醚化、水解反应,"一锅法"得到标题化合物,总收率达74.6%,产物纯度达99.5%。

Improved Process of 2-Propylthio-3-trifluoromethyl-phenol as Intermediate of Penoxsulam

An improved process was proposed to synthesize 2-propylthio-3-trifluoromethylphenol,a key intermediate of penoxsulam.The new route employed m-trifluoromethylphenol as raw material and 3,4-dihydro-2H-pyran as phenolic hydroxylprotective agent.Comparing with hypertoxic traditional agent such as hypertoxicchloromethyl methyl ether,3,4-dihydro-2H-pyran safer and fairly low toxicity.The target product was obtained by thioetherification and hydrolysis sequentially in a one-pot way,a total yield of 74.6％ with 99.5％ product purity.