一锅法制备四氢苯并呋喃衍生物

以取代苯乙酮为起始原料,经由分子碘的卤代,与吡啶成盐得到氮叶里德化合物,再进一步在碱存在下与1,3-环己二酮、取代苯甲醛反应,一锅法高收率制备得到目标化合物,该方法不需提前制备a-卤代苯乙酮或者不饱和羰基化合物,具有操作简便、条件温和、产率较高等特点。目标产物经~1HNMR、~(13)CNMR、IR和MS进行确认。

One-pot Synthesis of Tetrahydrobenzofuran Derivatives

A general one-pot synthesis of tetrahydrobenzofurans was developed,which starting from substituted acetophenones,benzaldehydes,and 1,3-cyclohexanedione,the key point of this method is the formation of the ylide in one pot just by halogenation of the acetophenone with the assistance of pyridine.This approach has many advantages over conventional ones,such as mild reaction conditions,simple experimental procedures and high yields,as well as without needing to synthesis of a-haloacetophenone or unsaturated carbonyl compound in advance.And all the target products are confirmed by 1HNMR,13CNMR,IR and MS.