| (E)-3-(3,4-二羟基苯基)丙烯酸的合成 |
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| 引用本文： | 方方,吉爱国. (E)-3-(3,4-二羟基苯基)丙烯酸的合成[J]. 化学试剂, 2006, 28(12): 749-750 |
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| 作者姓名： | 方方 吉爱国 |
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| 作者单位： | 山东大学,药学院,山东,济南,250012;安徽中医学院,药学院,安徽,合肥,230031;山东大学,药学院,山东,济南,250012 |
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| 摘 要： | 以3,4-二甲氧基苯甲醛为原料,微波辐射下与丙二酸发生Knoevenagel反应后,在TMSCl/NaI/CH3CN体系中脱甲基合成了标题化合物。探讨了影响产率的因素并对终产物进行了结构表征,总收率为90%。
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| 关 键 词： | (E)-3-(3,4-二羟基苯基)丙烯酸 Knoevenagel反应 脱甲基 |
| 文章编号： | 0258-3283（2006）12-0749-02 |
| 收稿时间： | 2006-05-15 |
| 修稿时间： | 2006-05-15 |
Synthesis of (E)-3-(3,4-dihydroxyphenyl) acrylic acid |
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| FANG Fang,JI Ai-guo. Synthesis of (E)-3-(3,4-dihydroxyphenyl) acrylic acid[J]. Chemical Reagents, 2006, 28(12): 749-750 |
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| Authors: | FANG Fang JI Ai-guo |
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| Affiliation: | 1. School of Pharmaceutical Science, Shandong University, Jinan 250012, China; 2. College of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei 230031, China |
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| Abstract: | (E)-3-(3,4-Dihydroxyphenyl)acrylic acid was prepared from 3,4-dimethoxybenzaldehyde via the Knoevenagel reaction and demethylation.The first step was activated by microwave radiation and the second step reacted in the system of TMSCl/NaI/CH_3CN.The optimum conditions of the two steps were studied.The structural characterization of the final product was investigated by IR spectrum,(()~1HNMR) and elemental analysis.The overall yield was 90%. |
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| Keywords: | (E)-3-(3 4-dihydroxyphenyl)acrylic acid Knoevenagel reaction demethylation |
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