Thoracic tumors in children with neurofibromatosis-1 |
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Authors: | EK Schorry AH Crawford JC Egelhoff AM Lovell HM Saal |
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Affiliation: | Boyd Orr Research Centre, University of Aberdeen, Bucksburn, Scotland, UK. |
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Abstract: | Lymphocytes were isolated from volunteers before and after receiving a single supplement of vitamin C, vitamin E or beta-carotene. The lymphocytes were treated with H2O2, and DNA strand breaks were measured by single cell gel electrophoresis (the comet assay). Significant protection against oxidative DNA damage was evident 2-4 h after vitamin C intake, and 18-24 h after consumption of the other antioxidants. Lymphocytes from smokers were more sensitive to DNA damage than those from non-smokers, and they showed at least as great a protective effect with antioxidants. |
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