Acute dietary PCPA treatment decreases the KD of brain [3H]5-HT binding in rainbow trout, Oncorhynchus mykiss, fed a high carbohydrate diet |
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| Authors: | WL Johnston NT Glanville |
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| Affiliation: | Department of Nutritional Sciences, University of Guelph, Ontario, Canada. |
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| Abstract: | Two experiments were conducted to determine the effect of dietary PCPA on brain [3H]5-HT binding in rainbow trout. [3H]5-HT binding was quantitatively similar to that observed in mammalian species. Dietary treatment with PCPA had no effect on the Bmax of [3H]5-HT binding in either experiment while the KD was decreased in Experiment 1. These results demonstrate that [3H]5-HT binding affinity is increased following short term inhibition of 5-HT synthesis by PCPA in rainbow trout. |
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