| N-取代-5-芳基-1,3,4-噁二唑-2-氨基的合成及其晶体结构 |
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| 引用本文： | 陈晓芳,刘学峰,奚立民.N-取代-5-芳基-1,3,4-噁二唑-2-氨基的合成及其晶体结构[J].化学世界,2010,51(4). |
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| 作者姓名： | 陈晓芳 刘学峰 奚立民 |
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| 作者单位： | 台州职业技术学院生物与化学工程系,浙江台州,318000 |
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| 基金项目： | 浙江省科技计划重大项目 |
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| 摘 要： | 以氨基脲衍生物作为起始原料,经过腙化、氯化和分子内环化三步反应合成了与文献报道不一致的N-取代-5-芳-基1,3,4-噁二唑-2-氨基类化合物(总收率42.0%~68.7%)。产物经过IR,1H NMR,MS和元素分析表征。此外,2-氨基-5苯基-1,3,4-噁二唑(4a)经过X射线单晶衍射确证其为1,3,4-噁二唑类化合物,并非文献报道的1,4-二氢-1,2,4,5-四嗪类化合物。
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| 关 键 词： | 1 3 4-噁二唑 晶体结构 1 2 4 5-四嗪 合成 |
Synthesis and Crystal Structure of N-Substituted-5-aryl-1,3,4-oxadiazole-2-amine |
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| CHEN Xiao-fang,LIU Xue-feng,XI Li-min.Synthesis and Crystal Structure of N-Substituted-5-aryl-1,3,4-oxadiazole-2-amine[J].Chemical World,2010,51(4). |
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| Authors: | CHEN Xiao-fang LIU Xue-feng XI Li-min |
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| Abstract: | N-Substituted-5-aryl-1,3,4-oxadiazole-2-amine was synthesized by a three-step reaction in overall yields of 42.0%～68.7%.The products were characterized by IR,~1H NMR,MS and elemental analysis.Furthermore,the single crystal X-ray study of 5-phenyl-1,3,4-oxadiazole-2-amine(4a)indicated that this compound belonged to 1,3,4-oxadiazole derivatives,not to 1,4-dihydro-1,2,4,5-tetrazine derivatives. |
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| Keywords: | 1 3 4-oxadiazole crystal structure 1 2 4 5-tetrazine synthesis |
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