| 二羟乙酸薄荷酯的制备过程中副产物的研究 |
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| 引用本文： | 龙中柱,徐轶,王春梅,吴彦,蔡水洪,苏克曼.二羟乙酸薄荷酯的制备过程中副产物的研究[J].化学世界,2009,50(7). |
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| 作者姓名： | 龙中柱 徐轶 王春梅 吴彦 蔡水洪 苏克曼 |
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| 作者单位： | 1. 上海东岳生物化工有限公司,上海,200237
2. 中国药科大学药学院,江苏,南京,210009 |
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| 摘 要： | 利用波谱分析技术鉴定了二羟乙酸薄荷酯制备过程中的杂质结构,并由此推测该杂质产生的原因、机理,提出抑制形成该杂质的副反应的方法,为工业化大生产奠定了基础。
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| 关 键 词： | 二羟乙酸薄荷酯 杂质结构分析 1H NMR IR |
Study on the By-product Produced During the Scale-up of Drug Intermediate L-Menthol Glyoxylate |
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| LONG Zhong-zhu,XU Yi,WANG Chun-mei,WU Yan,CAI Shui-hong,SU Ke-man.Study on the By-product Produced During the Scale-up of Drug Intermediate L-Menthol Glyoxylate[J].Chemical World,2009,50(7). |
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| Authors: | LONG Zhong-zhu XU Yi WANG Chun-mei WU Yan CAI Shui-hong SU Ke-man |
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| Affiliation: | 1. Shanghai Dongyue Biochem. Co. Ltd.;Shanghai 200237;China;2. School of Pharmacy;China Medical University;Jiangsu Nanjing 210009;China |
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| Abstract: | The structure of the impurity in the preparation of L-menthol glyoxylate was identified by various spectroscopies. Furthermore,the cause and mechanism of the production of the impurity was discussed and the method for controlling the impurity lovel was suggested,providing the basis for the scale up of L-menthol glyoxylate. |
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| Keywords: | 1H NMR IR L-menthol glyxoylate impurity structure analysis 1H NMR IR |
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