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| 80MeV/u 12C6+离子辐照小鼠头部对脾脏细胞周期分布的影响 | |
| 引用本文： | 邴涛,党秉荣,谢漪,邱荣,李文建,郭红云,李雪萍,高清祥,郝冀方,王菊芳,张红.80MeV/u 12C6+离子辐照小鼠头部对脾脏细胞周期分布的影响[J].辐射研究与辐射工艺学报,2006,24(1):61-64. |
| 作者姓名： | 邴涛 党秉荣 谢漪 邱荣 李文建 郭红云 李雪萍 高清祥 郝冀方 王菊芳 张红 |
| 作者单位： | 1. 中国科学院近代物理研究所,兰州,730000 2. 甘肃省医学科学院,兰州,730050 3. 兰州大学生命科学院,兰州,730000 |
| 基金项目： | 国家西部之光人才培养计划;国家高技术研究发展计划(863计划);中国科学院兰州近代物理研究所资助项目;甘肃省青年科技基金 |
| 摘 要： | 研究重离子辐照小鼠头部对脾脏细胞周期分布的影响，为重离子放射治疗癌症和太空防护提供基础数据。80MeV／u能量的^12C^6＋对BALB／c小鼠头部给以0、0．5、1、2、4、10Gy的照射，用流式细胞仪测脾脏细胞周期分布。重离子辐照后36h，小鼠脾脏细胞S期细胞随着辐照剂量的增加显著减少（p〈0．05）；0．5Gy组、4Gy组和10Gy组出现G0／G0期阻滞明显阻滞（p〈0．05），1Gy组和2Gy组无显著变化（p〉0．05）；0．5Gy组G2／M期细胞显著减少（p〈0．01），其它剂量组明显阻滞（p〈0．05）。重离子辐照小鼠头部对小鼠脾脏细胞周期分布有明显影响。 |
| 关 键 词： | 神经内分泌系统 重离子辐照 脾脏 细胞周期分布 |
| 收稿时间： | 2005-07-05 |
| 修稿时间： | 2005-09-07 |
Spleen cell cycle changes of mice irradiated at head by 80MeV/u 12C+6 ions |
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| BING Tao,DANG Bingrong,XIE Yi,QIU Rong,LI Wenjian,GUO Hongyun,LI Xueping,GAO Qingxiang,HAO Jifang,WANG Jufang,ZHANG Hong.Spleen cell cycle changes of mice irradiated at head by 80MeV/u 12C+6 ions[J].Journal of Radiation Research and Radiation Processing,2006,24(1):61-64. | |
| Authors: | BING Tao DANG Bingrong XIE Yi QIU Rong LI Wenjian GUO Hongyun LI Xueping GAO Qingxiang HAO Jifang WANG Jufang ZHANG Hong |
| Affiliation: | 1.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000; 2Gansu Academy of Medical Sciences, Lanz.hou 730050; Institute of Biological Sciences, Lanzhou University, Lanzhou 730000 |
| Abstract: | After whole head irradiation (WHI) of mice with 12 C 6 ions (80 MeV /u), changes of cycle distribu-tion of spleen cells were studied, in an attempt to provide basic data for heavy ion radiotherapy and space radiation protection. The heads of the BALB/c mice were irradiated with 0, 0.5, 1, 2, 4 or 10 Gy by the 12 C 6 ions. The cell cy-cle distribution was analyzed by flow cytometry. Thirty-six hours after the irradiation, the S phase cells were reduced significantly (p<0.05) with increasing doses. The 0.5 Gy, 4 Gy and 10 Gy WHI groups showed evident arrest in G1 / G0 phase (p<0.05), but the 1 Gy and 2 Gy WHI groups had no significant arrest (p>0.05). G2 / M phase of the 0.5 Gy WHI group was reduced markedly (p<0.01), while the other groups showed obvious arrest (p<0.05). After WHI of mice with the heavy ions, spleen cell cycle distribution of mice changed significantly. |
| Keywords: | Neuro-endocrine System Heavy ion irradiation Spleen Cell cycle distribution |
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