Extracellular Vesicles and Renal Fibrosis: An Odyssey toward a New Therapeutic Approach |
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| Authors: | Maja Kosanovi&#x ,Alicia Llorente,Sofija Glamo
lija,Jos M. Valdivielso,Milica Bozic |
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| Affiliation: | 1.Institute for the Application of Nuclear Energy, INEP, University of Belgrade, 11080 Belgrade, Serbia; (M.K.); (S.G.);2.Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, 0379 Oslo, Norway;3.Department for Mechanical, Electronics and Chemical Engineering, Oslo Metropolitan University, 0167 Oslo, Norway;4.Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen RETIC, 25196 Lleida, Spain; |
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| Abstract: | Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight advantages and future perspectives of the therapeutic applications of EVs in renal diseases. |
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| Keywords: | extracellular vesicles exosomes cellular communication renal fibrosis CKD therapeutic agents regeneration renoprotection mesenchymal stem cells cell-free therapeutic |
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