Aqueous extracts of Vaccinium corymbosum as inhibitors of Staphylococcus aureus |
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| Affiliation: | 1. Department of Neurology, Cardinal Tien Hospital, New Taipei City, Taiwan;2. School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan;3. Section of Radiation Oncology, Cardinal Tien Hospital, Taiwan;4. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;5. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan;6. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;1. Research and Inspection Center of Traditional Chinese Medicine and Ethnomedicine, National Institutes for Food and Drug Control, State Food and Drug Administration, Beijing 100050, China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. Department of Applied Physics, Avda de Elvas s/n, 06006, Badajoz, Spain;2. Department of Biomedical Sciences, Avda de Elvas s/n, 06006, Badajoz, Spain;3. Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Avda de Elvas s/n, 06006, Badajoz, Spain;4. University Institute of Extremadura Sanity Research (INUBE), University of Extremadura, Avda de Elvas s/n, 06006, Badajoz, Spain;1. Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry 607402, India;2. Mahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry 607402, India;3. School of Biological Sciences, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry 607402, India;4. Department of Biotechnology,Jeppiaar engineering college, chennai 600119, India |
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| Abstract: | Staphylococcus aureus has been established has one of the most common pathogens causing nosocomial infections worldwide and also playing a role in for several outbreaks related to the consumption of contaminated foodstuffs. More recently, the discovery of methicillin resistant S. aureus (MRSA) in raw and processed foods increased the risk factor associated with S. aureus associated foodborne diseases and has led to the search for new sources of antimicrobial agents. Therefore the aim of this study is to evaluate, for the first time, the impact of Vaccinium corymbosum L., fruit and leaf, infusions and decoctions upon methicillin resistant (MRSA) and sensitive S. aureus (MSSA). In order to accomplish these objectives V. corymbosum extracts were characterized and inhibition halos, inhibitory concentrations, impact upon enzymatic activity and biofilm formation were assessed. The results obtained showed that major compounds present in V. corymbosum constitution were quercetin-3-glucoside, chlorogenic and cafeic acids. MRSA and MSSA growth was inhibited at 12.5 mg/mL, for leaf, and 50 mg/mL, for fruit, and sub-MIC concentrations presented inhibition percentages as high as 3 log of viable cells and 47% of biomass. Furthermore DNase and coagulase were also inhibited at sub-MIC concentrations of the extracts. The results obtained imply an effective antibacterial and antibiofilm activity of these extracts towards MRSA and MSSA, thus revealing an interest potential for application in the food industry either as a functional ingredient or a preservative. |
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| Keywords: | MRSA MSSA Antibiofilm Enzymatic activity |
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