| N,N-二乙基氨基乙基-4-甲基苄基醚及其类似物的合成 |
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| 引用本文： | 宋瑞峰,林启君.N,N-二乙基氨基乙基-4-甲基苄基醚及其类似物的合成[J].化学世界,2008,49(12). |
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| 作者姓名： | 宋瑞峰 林启君 |
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| 作者单位： | 1. 苏州科技学院化学与生物工程学院,江苏,苏州,215009
2. 山东大学化学与化工学院,山东,济南,250100 |
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| 摘 要： | 采用相转移催化的方法合成了5个N,N-二烷基氨基乙基-4-甲基苄基醚化合物,产率为73%~89%。适宜的反应条件是:以二烷基氨基乙醇、4-甲基氯化苄为原料,四丁基溴化铵为相转移催化剂(PTC),氢氧化钠为碱,甲苯为溶剂,摩尔比n(R1R2NCH2CH2OH)∶n(MeArCH2C1)∶n(NaOH)∶n(PTC)=1.1∶1∶2∶0.05,反应时间为2 h,温度为70℃。产物经过沸点、元素分析、红外光谱、氢质子核磁共振谱给予确证。
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| 关 键 词： | N N-二烷基氨基乙基-4-甲基苄基醚 相转移催化 4-甲基氯化苄 合成 |
Syntheses of N,N-Diethylaminoethyl-4-methylbenzyl Ether and Its Analogues |
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| SONG Ru-feng,LIN Qi-jun.Syntheses of N,N-Diethylaminoethyl-4-methylbenzyl Ether and Its Analogues[J].Chemical World,2008,49(12). |
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| Authors: | SONG Ru-feng LIN Qi-jun |
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| Abstract: | Five compounds N,N-dialkylaminoethyl-4-methylbenzyl ether were synthesized with good yield(73%～89%)from the reaction of dialkylaminoethanol with 4-methylbenzyl chloride by using Bu_4NBr as a phase-transfer catalyst,sodium hydroxide as base,toluene as solvent molar ration n(R~1R~2NCH_2CH_2OH): n(MeArCH_2Cl)∶n(NaOH)∶n(PTC)=1.1∶1∶2∶0.05,for 2 h at 70(℃).Structure of the products was confirmed by bp determination,elemental analysis,IR and ~1H NMR spectrometry. |
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| Keywords: | N N-dialkylaminoethyl-4-methylbenzyl ether phase transfer catalysis 4-methylbenzyl chloride synthesis |
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