Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly(l-lactide) fibrous membrane |
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Authors: | Shen Liu Jingwen Zhao Hongjiang Ruan Wei Wang Tianyi Wu Wenguo Cui Cunyi Fan |
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Affiliation: | 1. Department of Orthopaedics, Shanghai Sixth People''s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, PR China;2. Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215007, PR China;3. School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, PR China;4. Department of Orthopaedic Surgery, 2nd Affiliated hospital of Nanjing Medical University, Nanjing Medical University, 121 Jiang Jia Yuan, Nanjing 210011, PR China |
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Abstract: | The complications of tendon injury are frequently compromised by peritendinous adhesions and tendon sheath infection. Physical barriers for anti-adhesion may increase the incidence of postoperative infection. This study was designed to evaluate the potential of silver nanoparticles (AgNPs)-loaded poly(l-lactide) (PLLA) electrospun fibrous membranes to prevent adhesion formation and infection. Results of an in vitro drug release study showed that a burst release was followed by sustained release from electrospun fibrous membranes with a high initial silver content. Fewer fibroblasts adhered to and proliferated on the AgNP-loaded PLLA electrospun fibrous membranes compared with pure PLLA electrospun fibrous membrane. In the antibacterial test, the AgNP-loaded PLLA electrospun fibrous membranes can prevent the adhesion of Gram-positive Staphylococcus aureus and Staphylococcus epidermidis and Gram-negative Pseudomonas aeruginosa. Taken together, these results demonstrate that AgNP-loaded PLLA electrospun fibrous membranes have the convenient practical medical potential of reduction of infection and adhesion formation after tendon injury. |
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