Effects of fluid flow shear rate and surface roughness on the calcification of polymeric heart valve leaflet |
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Authors: | Parnian Boloori_Zadeh Scott C Corbett Hamid Nayeb-Hashemi |
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Affiliation: | 1. Department of Mechanical and Industrial Engineering, Northeastern University, 334 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115-5000, United States;2. Research and Development, Abiomed Inc., 22 Cherry Hill Drive, Danvers, MA 01923, United States |
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Abstract: | Surface defects, blood flow shear rates and mechanical stresses are contributing factors in the calcification process of polymeric devices exposed to the blood flow. A number of experiments were performed to evaluate the effect of surface defects such as roughness and cracks and flow shear rate on the calcification process of a polyurethane material used in the design of prosthetic heart valves. Results showed that polyurethane surface gets calcified and the calcification is more pronounced at the lower shear rates. Roughness and cracks both increase the calcification levels. The results also suggest very little diffusion of calcium to the subsurface indicating that calcification of a polyurethane material, is a surface phenomenon. Based on a simple peeling test, the bond strength between the calcified layer and polyurethane was found to be extremely weak, suggesting that the bonding is in the form of Van-der-Waals. A limited set of experiments with polycarbonate showed that polycarbonate is less prone to calcification compared to polyurethane (p values less than 0.05), indicating its potential application in medical devices exposed to blood flow. |
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