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Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
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| Authors: | Ângelo M.L. Denadai Jeferson G. Da Silva Pedro P.G. Guimarães Leonardo Bertolini S. Gomes Antonio S. Mangrich Edivaltrys I.P. de Rezende Izabela M.P. Daniel Heloísa Beraldo Rubén D. Sinisterra |
| Affiliation: | 1. Departamento de Farmácia, Universidade Federal de Juiz de Fora (UFJF), Campus Governador Valadares, Av. Dr. Raimundo Monteiro de Rezende, 330, Centro, 35010-177 Governador Valadares, MG, Brazil;2. Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), 31270-901 Belo Horizonte, MG, Brazil;3. Faculdade Presidente Antônio Carlos, UNIPAC, Campus Ipatinga, 35164-779, Ipatinga-MG, Brazil;4. Departamento de Química, Centro Politécnico, Universidade Federal do Paraná (UFPR), 81531-970 Curitiba, PR, Brazil;5. Instituto Nacional de Ciência e Tecnologia de Energia e Ambiente, Instituto de Química, Universidade Federal da Bahia (UFBA), 40170-290 Salvador, BA, Brazil |
| Abstract: | Reaction of highly soluble orally active, non-peptide antihypertensive drug losartan with copper(II) leads to the spontaneous formation of a very insoluble 2:1 covalent complex, which self assembles in a hydrophobic supramolecular structure of nanometric dimensions. Thermal analysis showed that Los/Cu(II) complex presents intermediate stability in comparison with its precursors KLos and Cu(OAc)2·H2O. Isothermal titration calorimetry indicated complexation to be a stepwise process, driven by enthalpy and entropy. Zeta potential and DLS measurements showed that it is possible to control the size and charge of nanoprecipitates by adjusting the relative concentration of Los? and Cu(II). |
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