Investigation of emulsified,acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery |
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| Authors: | Guohou Miao Xiaofeng Chen Hua Dong Liming Fang Cong Mao Yuli Li Zhengmao Li Qing Hu |
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| Affiliation: | 1. School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 China;2. National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006 China;3. Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006 China;4. School of Biological Science and Engineering, South China University of Technology, Guangzhou 510006, China |
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| Abstract: | Acid-catalyzed mesoporous bioactive glass microspheres (MBGMs-A) and acid-alkali co-catalyzed mesoporous bioactive glass microspheres (MBGMs-B) were successfully synthesized via combination of sol-gel and water-in-oil (W/O) micro-emulsion methods. The structural, morphological and textural properties of mesoporous bioactive glass microspheres (MBGMs) were characterized by various techniques. Results show that both MBGMs-A and MBGMs-B exhibit regularly spherical shape but with different internal porous structures, i.e., a dense microstructure for MBGMs-A and internally porous structure for MBGMs-B. 29Si NMR data reveal that MGBMs have low polymerization degree of silica network. The in vitro bioactivity tests indicate that the apatite formation rate of MBGMs-B was faster than that of MBGMs-A after soaking in simulated body fluid (SBF) solution. Furthermore, the two kinds of MBGMs have similar storage capacity of alendronate (AL), and the release behaviors of AL could be controlled due to their unique porous structure. In conclusion, the microspheres are shown to be promising candidates as bone-related drug carriers and filling materials of composite scaffold for bone repair. |
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