Effect of phospholipase a upon brain cholesterol ester formation |
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| Authors: | Robert B Ramsey A N Davison |
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| Affiliation: | 1. Department of Neurology, St. Louis University, 63104, St. Louis, Missouri
2. Department of Neurochemistry Institute of Neurology, The National Hospital, Queen Square, WC1N 3BG, London, England
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| Abstract: | On addition of snake venom phospholipase A to homogenates of rat brain we have been able to show increased ester formation. Within certain limits, the amount of ester formed was dependent upon the amount of phospholipase added. The fatty acid patterns of free fatty acid released and of cholesteryl ester fatty acid formed during 18 hr incubation were compared. Although fatty acid patterns were different, the data were still consistent with the hypothesis that, in demyelination, a neural phospholipase A may play a role in cholesteryl ester deposition. |
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