| ANALYSIS OF PULSATILE FLOW IN THE PARALLEL-PLATE FLOW CHAMBER WITH SPATIAL SHEAR STRESS GRADIENT |
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| 作者姓名： | QIN Kai-rong HU Xu-qu LIU Zhao-rong |
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| 作者单位： | QIN Kai-rong，HU Xu-qu Department of Engineering Mechanics，Shanghai Jiaotong University，Shanghai 200240，China，LIU Zhao-rong Institute of Biomechanics，Fudan University，Shanghai 200433，China |
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| 摘 要： | The Parallel-Plate Flow Chamber (PPFC), of which the height is far smaller than its own length and width, is one of the main apparatus for the in-vitro study of the mechanical behavior of cultured vascular Endothelical Cells (ECs) exposed to fluid shear stress. The steady flow in different kinds of PPFC has been extensively investigated, whereas, the pulsatile flow in the PPFC has received little attention. In consideration of the characteristics of geometrical size and pulsatile flow in the PPFC, the 3-D pulsatile flow was decomposed into a 2-D pulsatile flow in the vertical plane, and an incompressible plane potential flow in the horizontal plane. A simple method was then proposed to analyze the pulsatile flow in the PPFC with spatial shear stress gradient. On the basis of the method, the pulsatile fluid shear stresses in several reported PPFCs with spatial shear stress gradients were calculated. The results were theoretically meaningful for applying the PPFCs in-vitro, to simulate the pulsatile fluid shear stress environment, to which cultured ECs were exposed.
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| 关 键 词： | 脉动流 流体剪切应力 时空应力梯度 血管内皮细胞 平行平板流动腔 |
| 收稿时间： | 2006-08-31 |
| 修稿时间： | 2006-10-21 |
ANALYSIS OF PULSATILE FLOW IN THE PARALLEL-PLATE FLOW CHAMBER WITH SPATIAL SHEAR STRESS GRADIENT |
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| QIN Kai-rong HU Xu-qu LIU Zhao-rong.ANALYSIS OF PULSATILE FLOW IN THE PARALLEL-PLATE FLOW CHAMBER WITH SPATIAL SHEAR STRESS GRADIENT[J].Journal of Hydrodynamics,2007,19(1):113-120. |
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| Authors: | QIN Kai-rong HU Xu-qu LIU Zhao-rong |
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| Affiliation: | 1. Department of Engineering Mechanics, Shanghai Jiaotong University, Shanghai 200240, China;2. Institute of Biomechanics, Fudan University, Shanghai 200433, China;1. Department of Biomedical Engineering, Lund University, Lund, Sweden;2. School of Business and Engineering, PRODEA Research Group, Halmstad University, Halmstad, Sweden;3. Health and Welfare, Dala Sports Academy, Dalarna University, Falun, Sweden;4. Clinical Physiology and Nuclear Medicine Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden;1. Department of Mathematics, The University of Burdwan, Burdwan-713104, W. B., India;2. Department of Mathematics, Department of Mechanical, Materials and Aerospace Engineering, University of Central Florida, Orlando, Florida 32816 – 1364, USA;1. Department of Mechanical Engineering, Faculty of Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran;2. Khomeinishahr Branch, Department of Mechanical Engineering, Islamic Azad University, Isfahan, Iran;3. Department of Mechanical Engineering, University of Utah, 84112, Salt Lake City, UT, United States |
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| Abstract: | The Parallel-Plate Flow Chamber (PPFC), of which the height is far smaller than its own length and width, is one of the main apparatus for the in-vitro study of the mechanical behavior of cultured vascular Endothelical Cells (ECs) exposed to fluid shear stress. The steady flow in different kinds of PPFC has been extensively investigated, whereas, the pulsatile flow in the PPFC has received little attention. In consideration of the characteristics of geometrical size and pulsatile flow in the PPFC, the 3-D pulsatile flow was decomposed into a 2-D pulsatile flow in the vertical plane, and an incompressible plane potential flow in the horizontal plane. A simple method was then proposed to analyze the pulsatile flow in the PPFC with spatial shear stress gradient. On the basis of the method, the pulsatile fluid shear stresses in several reported PPFCs with spatial shear stress gradients were calculated. The results were theoretically meaningful for applying the PPFCs in-vitro, to simulate the pulsatile fluid shear stress environment, to which cultured ECs were exposed. |
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| Keywords: | Pulsatile flow fluid shear stress spatial shear stress gradient parallel-plate flow chamber cultured endothelial cells cell mechanics |
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