| 聚天冬氨酸交联温敏性水凝胶的药物缓释性能 |
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| 引用本文： | 于跃芹,常宪智,田红杰,许洋. 聚天冬氨酸交联温敏性水凝胶的药物缓释性能[J]. 高分子材料科学与工程, 2009, 25(1): 79-82 |
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| 作者姓名： | 于跃芹 常宪智 田红杰 许洋 |
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| 作者单位： | 青岛科技大学化学与分子工程学院,山东,青岛,266042;青岛科技大学化学与分子工程学院,山东,青岛,266042;青岛科技大学化学与分子工程学院,山东,青岛,266042;青岛科技大学化学与分子工程学院,山东,青岛,266042 |
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| 基金项目： | 国家自然科学基金资助项目(20476049);;山东省自然科学基金资助项目(Y2006B10) |
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| 摘 要： | 选用牛血清蛋白(BSA)和5-氟尿嘧啶(5-FU)为模型药物,以聚天冬氨酸交联温敏性水凝胶为载体材料,采用包埋法制备了载药水凝胶,研究了水凝胶的载药和释药性能。水凝胶对BSA和5-FU的包埋率均大于98%。37℃时,水凝胶中丙烯酸用量越大,BSA的释放率越低;交联剂用量对BSA的释放率无显著影响。25℃时,丙烯酸用量越大,5-FU的释放率越大;交联剂用量越大,5-FU的释放率越小。37℃时,丙烯酸用量越小,5-FU的释放率越大;交联剂用量越大,5-FU的释放率越小。
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| 关 键 词： | 温敏性水凝胶 药物缓释 5-氟尿嘧啶 牛血清蛋白 |
Releasing Property of the Thermoresponsive Hydrogels Cross-Linked with Polyaspartic Acid for Drug Delivery System |
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| YU Yue-qin,CHANG Xian-zhi,TIAN Hong-jie,XU Yang. Releasing Property of the Thermoresponsive Hydrogels Cross-Linked with Polyaspartic Acid for Drug Delivery System[J]. Polymer Materials Science & Engineering, 2009, 25(1): 79-82 |
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| Authors: | YU Yue-qin CHANG Xian-zhi TIAN Hong-jie XU Yang |
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| Affiliation: | College of Chemistry and Molecular Engineering;Qingdao University of Science and Technology;Qingdao 266042;China |
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| Abstract: | A preliminary study of the thermoresponsive hydrogels cross-linked with polyaspartic acid for drug delivery system was performed with model drugs of 5-fluorouracil(5-FU) and bovine serum albumin(BSA).It is found that the releasing rate and cumulative quantity of BSA decrease with the increase of acrylic acid(AAc) content at 37 ℃ in PBS,and cross-linker content has little effect on the BSA releasing rate.The releasing rate and cumulative quantity of 5-FU increase with the increase of AAc content,and decrease with the increase of cross-linker content at 25 ℃ in PBS,while the releasing rate and quantity of 5-FU decrease with increasing AAc content and cross-linker content in the hydrogels at 37 ℃ in PBS. |
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| Keywords: | thermorespone hydrogel drug release 5-fluorouracil bovine serum albumin |
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